pathwayPCA - Integrative Pathway Analysis with Modern PCA Methodology and Gene Selection

pathwayPCA is an integrative analysis tool that implements the principal component analysis (PCA) based pathway analysis approaches described in Chen et al. (2008), Chen et al. (2010), and Chen (2011). pathwayPCA allows users to: (1) Test pathway association with binary, continuous, or survival phenotypes. (2) Extract relevant genes in the pathways using the SuperPCA and AES-PCA approaches. (3) Compute principal components (PCs) based on the selected genes. These estimated latent variables represent pathway activities for individual subjects, which can then be used to perform integrative pathway analysis, such as multi-omics analysis. (4) Extract relevant genes that drive pathway significance as well as data corresponding to these relevant genes for additional in-depth analysis. (5) Perform analyses with enhanced computational efficiency with parallel computing and enhanced data safety with S4-class data objects. (6) Analyze studies with complex experimental designs, with multiple covariates, and with interaction effects, e.g., testing whether pathway association with clinical phenotype is different between male and female subjects. Citations: Chen et al. (2008) <https://doi.org/10.1093/bioinformatics/btn458>; Chen et al. (2010) <https://doi.org/10.1002/gepi.20532>; and Chen (2011) <https://doi.org/10.2202/1544-6115.1697>.

Last updated 24 days ago

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7.74 score 11 stars 42 scripts 170 downloads

mvMonitoring - Multi-State Adaptive Dynamic Principal Component Analysis for Multivariate Process Monitoring

Use multi-state splitting to apply Adaptive-Dynamic PCA (ADPCA) to data generated from a continuous-time multivariate industrial or natural process. Employ PCA-based dimension reduction to extract linear combinations of relevant features, reducing computational burdens. For a description of ADPCA, see <doi:10.1007/s00477-016-1246-2>, the 2016 paper from Kazor et al. The multi-state application of ADPCA is from a manuscript under current revision entitled "Multi-State Multivariate Statistical Process Control" by Odom, Newhart, Cath, and Hering, and is expected to appear in Q1 of 2018.

Last updated 1 years ago

5.24 score 4 stars 29 scripts 202 downloads

CTNote - CTN Outcomes, Treatments, and Endpoints

The Clinical Trials Network (CTN) of the U.S. National Institute of Drug Abuse sponsored the CTN-0094 research team to harmonize data sets from three nationally-representative clinical trials for opioid use disorder (OUD). The CTN-0094 team herein provides a coded collection of trial outcomes and endpoints used in various OUD clinical trials over the past 50 years. These coded outcome functions are used to contrast and cluster different clinical outcome functions based on daily or weekly patient urine screenings. Note that we abbreviate urine drug screen as "UDS" and urine opioid screen as "UOS". For the example data sets (based on clinical trials data harmonized by the CTN-0094 research team), UDS and UOS are largely interchangeable.

Last updated 11 months ago

4.78 score 1 stars 20 scripts 190 downloads